Prevention and Treatment In Utero of Autoimmune-Associated Congenital Heart Block
نویسندگان
چکیده
منابع مشابه
Pathophysiology of autoimmune-associated congenital heart block
Congenital heart block (CHB), detected at or before birth, in a structurally normal heart, is strongly associated with autoantibodies to SSA/Ro-SSB/La ribonucleoproteins. The historical hallmark of CHB is complete atrioventricular block (AVB) which is irreversible. CHB occurs in 2% of primigravid mothers with anti-Ro/La antibodies, and in 20% of women who had a previous CHB offspring. Although ...
متن کاملWhich Intrauterine Treatment for Autoimmune Congenital Heart Block?
Autoimmune Congenital Heart Block (CHB) is considered an immune mediated manifestation, caused by the action of maternal autoantibodies anti-Ro/SSA and anti-La/SSB on fetal cardiac tissues. The incidence of CHB is 2% in anti-Ro/SSA positive women, 3% when both anti-Ro/SSA and anti-La-SSB are positive. In the subsequent pregnancies the risk of recurrence is 9 times higher. The antenatal diagnosi...
متن کاملOutcome of isolated congenital complete heart block diagnosed in utero.
OBJECTIVE To establish identifiable prenatal factors in fetal heart block which might predict death in utero, the need for intervention, or the probability of pacemaker requirement. SETTING Tertiary referral unit for fetal echocardiography. SUBJECTS 36 fetuses with congenital complete heart block and structurally normal hearts identified between 1980 and 1993. METHODS Maternal anti-Ro ant...
متن کاملAutoimmune-associated Congenital Heart Block: A New Insight in Fetal Life
OBJECTIVE Congenital heart block (CHB) is a rare but life-threatening disorder. More than half of CHB cases are associated with maternal autoimmune, which are termed as autoimmune-associated CHB. This review summarized the recent research findings in understanding autoimmune-associated CHB, discussed the current diagnostic approaches and management strategies, and summarized the problems and fu...
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Background: Neonatal lupus erythematosus is an uncommon disease. Congenital complete heart block (CCHB) usually happens in neonates with maternal systemic lupus erythematosus. The most prevalent presentation of CCHBis bradycardiathatcanbediagnosed through an electrocardiogram. Case report: Here in, we present the case of a full-term male neonate with gestational age of 37 weeks and birth weigh...
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ژورنال
عنوان ژورنال: Cardiology in Review
سال: 2014
ISSN: 1061-5377
DOI: 10.1097/crd.0000000000000026